*Starred Review* Award-winning Virginia-based journalist Macy, author of best-sellers Factory Man (2014) and Truevine (2016), carefully constructs the through line from the midnineties introduction of the prescription painkiller OxyContin to the current U.S. opioid crisis: 300,000 deaths over the last 15 years, with that number predicted to double in the next 5. Its addictiveness initially far underreported, Oxy was outrageously marketed to doctors and overprescribed to patients, who quickly couldn't do without it. The much-later introduction of an abuse-resistant formula made heroin cheap and easily accessible, a natural next step. Macy's years of following the issue have earned her remarkable access to those suffering from opioid-addiction disorder as well as the people who tirelessly love and care for them and, in many cases, honor their memories. Again and again, she hears of the devotion the addicted claim to the drug, over every other aspect of their lives, and the motivating fear of dopesickness, gutting withdrawal symptoms. And despite its proven long-term success, medication-assisted treatment remains stigmatized and often too difficult to access. Although the realities are devastating, the doctors, the bereaved, and the advocates Macy introduces do offer hope. Hers is a crucial and many-faceted look at a still-unfolding national crisis, making this a timely and necessary read.--Bostrom, Annie Copyright 2010 Booklist